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Ryanair is scrapping its Stansted to Belfast route from October.
The airline is withdrawing a total of five routes from London Stansted, Liverpool, East Midlands, Bristol and Glasgow Prestwick to Belfast.
Services from Stansted to Belfast City Airport will end on 31 October 2010.
Passengers are advised to check with Ryanair for bookings made after that date.
The airline has supported the George Best Belfast City Airport's bid to secure a runway extension at its site in the east of the city.
It has been running on a reduced passenger load since its operations were established in October 2007. There are also restrictions on night-time flying.
A public inquiry was launched into the runway extension after vociferous opposition from local residents. It was suspended earlier this summer.