As George Michael/Mary J. Blige Download 'As' on iTunes
The actress is set to direct film for charity
The 42-year-old will work on a short about breast cancer for the Lifetime Project Five anthology series.
Demi Moore and Alicia Keys will also be involved in the project.
This is not the first time that Aniston goes behind the camera. In 2006 she co-directed the short Room 10, starring Robin Wright.