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The singer and hubby Jay-Z are allegedly close to the 57-year-old, and have reportedly asked her to be godmother to their three-week-old baby.
The superstar couple are great friends with the media mogul, who supposedly sent their daughter a trunk full of books upon the baby's birth.
Oprah Winfrey is famed for giving sage advice on her smash American TV show, and would no doubt offer baby Blue great spiritual guidance.
Blue Ivy has already become the youngest artist to ever hit the Billboard charts after her her gurgles were featured on Jay-Z's tribute track Glory.