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George has reportedly changed his mind on the starring role in 'The Man from U.N.C.L.E'.
The film is being directed by the critically acclaimed Steven Soderbergh, a close friend of George, but so far no official reason has been given as to Clooney's absence.
Production on the spy drama was due to begin in February, but the Ocean's Eleven star is no longer planning to lead the project, according to Deadline.com.
The movie is a big screen adaptation of the 1960s TV show which starred Robert Vaughn and David McCallum as secret agents.
Clooney was recently at the Venice Film Festival where his film The Ides of March, which he wrote, starred in and directed, was the opening film to be screened.
Check out the photos from the film festival below...