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They will be joined by Usher and The Edge at the gig to celebrate Bill Clinton's foundation.
The former President of the United States is celebrating the tenth anniversary of his charity and is delighted that such big stars will be playing at the gig.
In a statement to the Associated Press, he said: "(I'm) proud that some of today's most influential performers are coming together to raise awareness about the work of my foundation."
His charity strives to improve global health, strengthen economies worldwide, promote healthier childhoods and protect the environment.
Gaga, Usher, Bono and The Edge will be among the performers on-stage at the "Decade of Difference" concert on the 15th October.