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The documentary will follow the charitable royal on to Lesotho, the country in which he set up charity Sentebale in 2006.
The ITV documentary will follow the 32-year-old royal to Lesotho and will show Prince Harry as he 'travels through the beautiful and changing scenery to remote locations with his deeply personal aim of discovering the stories that he wants to show the world'.
It will show him following in his mothers philanthropic footsteps and committing to his incredible work in the African country.
As well as a broader overview of the work of Sentebale - meaning 'forget me not' in Sesotho - the ITV documentary will show the moment Prince Harry was reunited with teenager Mutsu whom he first met on a trip to the country in 2004.
Prince Harry first met 4-year-old Mutsu Potsane at Mants'ane children's home for orphans in 2004 (left). The little boy was very vulnerable and needed a lot of care and attention. It was in Lesotho in 2004 that Prince Harry and Prince Seeiso decided to start a charity to provide long term support to the most desperate children in Lesotho - the charity was named Sentebale. Mutsu and Prince Harry have formed a close friendship since their first meeting, and Mutsu writes to the Prince often to let him know how he is getting on with the help of Sentebale. They are pictured here (right) during their last reunion in 2014. #PrinceHarry #Sentebale #LesothosChildren
The pair bonded over the mutual loss of a parent as Harry lost his mother, Princess Diana in 1999.
The programme will also include an interview with the Prince by journalist Tom Bradby where he talks about why he founded his charity Sentebale and what he hopes to do in the future in Lesotho.