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The arrests were made in connection to the assault of a 28 year old man from Portsmouth on Thursday night.
Officers were called to reports of a stabbing at around 8:30pm in Sedgley Close.
A 34 year old woman and 18 year old man have been bailed until December 20th pending further, enquiries.
A 17 year old boy and an 18 year old man have also been bailed- until December 21st.
All of them are from Southsea.
The man was taken to hospital for treatment but has since been discharged.
Anyone with any information about this incident is asked to contact the Eastern Investigations Team on 101