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Earlier police told Heart as part of the investigation a property in the Lymington Road area, opposite the Coach Station, was searched when some suspect items were discovered which officers are describing "as potentially dangerous."
Six properties were evacuated as a precaution, so was the Innovation Centre across the road as it is mainly a glass fronted building police were concerned if there was an explosion people and passers by could be injured.
Approximately 50 to 60 people were evacuated from the Innovation Centre building.
The coach station has remained open throughout the day The Royal Navy Bomb disposal team from Plymouth arrived around 1:30pm and are currently at the scene.
The area between Upton Road and Upton Hill remains closed and police are advising the public to avoid the area at this time.