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25 February 2018, 13:14
The 13 year olds were taken to Crosshouse Hospital in Ayrshire on Saturday night.
The six children, who knew each other, were kept in hospital overnight for observations.
Detective inspector Fraser Normansell said: "Police were informed of six children who had been taken to Crosshouse Hospital after taking unwell.
"One line of inquiry is that they had taken a type of MDMA tablet, believed to be red, green or brown in colour bearing an owl logo.
"We want to remind the public that any drug can be dangerous and that you are putting your health at risk if you do take anything unknown to you.
"Anyone who feels unwell, or knows anyone who appears unwell after taking these substances should seek medical treatment as soon as possible."