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The two vehicle collision occurred on the A428 Bedford Road, close to the Warrington crossroads roundabout, at 7.37am on Monday morning.
The incident involved a blue Ford Focus and a white Volkswagen Caddy van.
The driver of the Ford Focus, a 29-year-old man, was taken to the Walsgrave Hospital in Coventry with serious leg injuries.
The driver of the white Volkswagen Caddy van, a 43-year-old man, was also taken to the Walsgrave Hospital with serious leg and chest injuries.
Thames Valley Police would like to speak anyone who may have seen the collision, or members of the public who may have seen either vehicle shortly before the collision.
If you have any information please contact PC Elizabeth Johnson via the Thames Valley Police Enquiry Centre on 101.
If you don't want to speak directly to the police you can contact the independent charity Crimestoppers anonymously on 0800 555 111 or online at www.crimestoppers-uk.org. No personal details are taken, information is not traced or recorded and you will not go to court.
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