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East Anglia's Children's Hospices is one of the charities that will benefit from the X Factor single.
This year it's a cover of Rose Royce's, "Wishing on a Star." It was launched this Sunday live on the show with the final 16 contestants performing it alongside JLS and One Direction.
All net proceeds will go to Together for Short Lives who work to ensure that all families of children unlikely to reach adulthood can make the most of their lives. East Anglia's Children's Hospices or EACH will use the money to help local children and families in Norfolk and Suffolk.
The charity was handpicked by Simon Cowell who is a patron and has the supported the organisation for a number of years.
He said: " I have seen first-hand the invaluable care and support they offer to thousands of young people and their families, so I am thrilled that the X Factor charity single this year will benefit this charity."
Graham Butland, Chief Executive of EACH says: " The X factor single gives EACH an extraordinary and unique opportunity to tell the public about the issues that face children and the families we support. There are some excellent care services out there, but families need much more support as they tell us how difficult it can be to find the right support at the right time. We want to see well co-ordinated services which are available from the moment a child is diagnosed, wherever families want them for as long as they are needed."
The single costs £3.99 and is available to download from http://xfactor.togetherforshortlives.org.uk and available to buy from all good high street stores.